Table 3. Antimicrobial susceptibility patterns of carbapenemase-producing and non-producing K. pneumoniae isolates.
| Antimicrobial agents | Carbapenemase positive (n = 28) | Carbapenemase negative (n = 104) | P-value | ||||
|---|---|---|---|---|---|---|---|
| S | I | R | S | I | R | ||
| Tetracycline | 5(17.9) | 4(14.3) | 19(67.9) | 16(15.4) | 11(10.6) | 77(74.0) | 0.791 |
| Gentamicin | 4(14.3) | 0(0.0) | 24(85.7) | 25(24.0) | 8(7.7) | 71(68.3) | 0.133 |
| Amikacin | 20(71.4) | 4(14.3) | 4(14.3) | 103(99.0) | 1(1.0) | 0(0.0) | <0.001* |
| Ciprofloxacin | 1(3.6) | 2(7.1) | 25(89.3) | 57(54.8) | 23(22.1) | 24(23.1) | <0.001* |
| Aztreonam | 0(0.0) | 3(10.7) | 25(89.3) | 13(12.5) | 27(26.0) | 64(61.5) | 0.016* |
| Piperacillin-tazobactam | 0(0.0) | 0(0.0) | 28(100.0) | 55(52.9) | 27(26.0) | 22(21.2) | <0.001* |
| Amoxicillin-clavulanate | 0(0.0) | 1(3.6) | 27(96.4) | 18(17.3) | 31(29.8) | 55(52.9) | <0.001* |
| SXT | 3(10.7) | 1(3.6) | 24(85.7) | 3(2.9) | 1(1.0) | 100(96.2) | 0.121 |
| Chloramphenicol | 7(25.0) | 10(35.7) | 11(39.3) | 52(50.0) | 3(2.9) | 49(47.1) | 0.018* |
| Cefoxitin | 0(0.0) | 0(0.0) | 28(100.0) | 62(59.6) | 12(11.5) | 30(28.8) | <0.001* |
| Ceftriaxone | 0(0.0) | 0(0.0) | 28(100.0) | 4(3.8) | 0(0.0) | 100(96.2) | 0.578 |
| Meropenem | 0(0.0) | 3(10.7) | 25(89.3) | 96(92.3) | 1(1.0) | 7(6.7) | <0.001* |
| Imipenem | 6(21.43) | 9(32.1) | 13(46.4) | 101(97.1) | 0(0.0) | 3(2.9) | <0.001* |
| Ertapenem | 0(0.0) | 2(7.1) | 26(92.9) | 93(89.4) | 3(2.9) | 8(7.7) | <0.001* |
S: Sensitive, I: Intermediate, R: Resistance, SXT: Trimethoprim-sulfamethoxazole
*P-value<0.05.