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. 2022 Apr 13;9:838654. doi: 10.3389/fmolb.2022.838654

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Copyright © 2022 Xia, Wang, Su, Lv, Yan, Guo and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Verification of prognostic ability of “E2F target” risk score in ICGC and GEO cohort. (A–B) Patients’ risk score–survival distribution map and gene expression heat map of “E2F target”-related genes in ICGC (left) and GEO (right) cohorts. (C) The “E2F target” risk score of patients with poor prognosis increased in both ICGC (left) and GEO (right) cohorts. (D) GSEA proved that at the high-risk group, the “E2F target” pathway was activated in both cohorts. (E–F) The ability of the “E2F target” risk score to distinguish high-risk patients was verified by PCA and tSNE in ICGC (Ea, Eb) and GEO (Fa, Fb) cohorts, and the prognosis of the high-risk group was significantly worse than the low-risk group (Ec, Ed, Fc, and Fd).