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. 2022 Apr 13;9:838654. doi: 10.3389/fmolb.2022.838654

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Copyright © 2022 Xia, Wang, Su, Lv, Yan, Guo and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Functional analysis and correlation analysis of stem cell characteristics and risk score. (A) Volcano diagram of DEGs between high- and low-risk groups. (B–D) KEGG and GO enrichment analysis showed that DNA replication, mismatch repair, cell growth, extracellular matrix remodeling, and binding pathways were active in patients with a high-risk, as well as the p53 pathway, wnt pathway, and stem cell differentiation. On the contrary, histidine metabolism was inhibited. (E–F) The “E2F target” risk score was positively correlated with DNAs and RNAs.