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. 2022 Apr 27;8(17):eabm2827. doi: 10.1126/sciadv.abm2827

Fig. 2. RNR large subunit structural conservation.

Fig. 2.

(A) EBV BORF2 (blue), E. coli RNR α subunit [Protein Data Bank (PDB): 6w4x; green], and human RNR α subunit (PDB: 6aui; tan) share a conserved α/β barrel catalytic core and overall architecture. β strands are highlighted in yellow for visual comparison, and an overlay is shown below. (B) Cartoon schematic of the proposed radical-based mechanism for ribonucleotide reduction with coordination between the small (pink) and large (blue) subunits. Zoom-in of the overlay of the active-site regions of EBV BORF2 (blue) and E. coli RNR α subunit (PDB: 6w4x, chain B; green), showing conservation of the tyrosine and cysteine residues involved in radical transfer and oxidation. Residue numbers correspond to BORF2.