Table 1.
Baseline demographic and clinical characteristics of patients with CD and healthy controls.
| Characteristics | Active stage (N=23) | Remission stage (N=20) | Healthy controls (N=18) | p-value |
|---|---|---|---|---|
| Age | 33.22±13.94 | 36.90±10.76 | 28.72±7.90 | .096 |
| Gender (male/female) | 17/6 | 14/6 | 15/3 | .701 |
| BMI (kg/m2) | 19.40±4.38 | 20.32±3.69 | 22.85±3.30 | .020 |
| CDAI score | 289.58±74.88 | 78.45±26.46 | N/A | <.001 |
| Lesion location* | ||||
| L1/L2/L3/L4 | 7/0/16/0 | 3/0/17/0 | N/A | .405 |
| Duration of disease (years) | 4.12±5.21 | 4.80±5.37 | N/A | .669 |
| NRS score (2002) | 2.91±1.00 | 3.55±1.43 | 0.39±1.20 | <.001 |
| Diet | ||||
| Regular diet/enteral nutrition/mixed diet | 17/6/2 | 13/2/5 | 18/0/0 | .011 |
| Smoke | ||||
| Never/past/current | 15/3/5 | 15/5/0 | 15/1/2 | .116 |
| Alcohol | ||||
| Never/past/current | 14/4/5 | 12/3/5 | 11/0/7 | .374 |
| Bristol stool scale# | ||||
| Type 1/2/3/4/5/6/7 | 0/2/1/6/5/8/1 | 0/1/2/1/3/12/1 | 1/0/4/13/0/0/0 | <.001 |
| Hematochezia (Yes/No) | 7/16 | 0/20 | 0/18 | .001 |
| Hematological index | ||||
| CRP (mg/L) | 49.82±57.39 | 3.63±1.71 | N/A | .001 |
| WBC (*109/L) | 7.28±3.71 | 5.41±1.30 | N/A | .031 |
| Hemoglobin (g/L) | 115.48±18.73 | 129.35±11.97 | N/A | .007 |
| Albumin (g/L) | 35.03±6.00 | 41.68±3.33 | N/A | <.001 |
| Prealbumin (mg/L) | 146.48±68.77 | 273.15±71.26 | N/A | <.001 |
| ESR (mm/h) | 33.09±18.79 | 20.00±15.21 | N/A | .017 |
| PCT (ng/ml) | 0.50±1.57 | 0.05±0.01 | N/A | .184 |
| IL-1 (pg/ml) | 6.90±6.56 | 6.91±4.38 | N/A | .996 |
| IL-6 (pg/ml) | 35.39±100.30 | 5.73±4.58 | N/A | .171 |
| IL-8 (pg/ml) | 101.51±107.93 | 86.93±99.05 | N/A | .649 |
| IL-10 (pg/ml) | 8.23±11.76 | 5.00±0 | N/A | .202 |
| Medicine | ||||
| Mesalazine/Azathioprine/Adamuzumab/Remicade/Steroids/Others | 11/5/7/6/2/2 | 1/6/5/12/0/1 | N/A | .018 |
BMI, body mass index; CDAI score, Crohn’s disease activity index score; NRS score (2002), nutrition risk screening score (2002); CRP, C-reactive protein; WBC, white blood cell; ESR, erythrocyte sedimentation rate; PCT, procalcitonin; IL-1, interleukin-1; IL-6, interleukin-6; IL-8, interleukin-8; IL-10, interleukin-10; N/A, not applicable.
Lesion location* L1: terminal ileum; L2: colon; L3: ileocolon; L4: upper digestive tract.
Bristol stool scale# Type 1: separate hard lumps, like nuts; type 2: sausage-shaped but lumpy; type 3: like a sausage but with cracks on its surface; type 4: like a sausage or snake, smooth and soft; type 5: soft blobs with clear-cut edges; type 6: fluffy pieces with ragged edges, a mushy stool; type 7: watery, no solid pieces.