Table 17.

An anti-tyrosinase activity of lignans.

Substances	Source of compounds	Substrate	Positive control (inhibitor)	Type of inhibition	Inhibition constant $K_i$ (mM)	Source of tyrosinase	The half-maximal inhibitory concentration ${\mathrm{IC}}_{50}$(µM)	References
Negundin A	Vitex negundo	L-DOPA	Kojic acid L-mimosine	NR	NR	Mushroom	10.06	Malik et al.120
Negundin B		L-DOPA		NR	NR	Mushroom	6.72	Malik et al.120
6-Hydroxy-4-(4-hydroxy-3-methoxy)-3-hydroxymethyl- 7-methoxy-3,4-dihydro-2-naphthaledehyde		L-DOPA		NR	NR	Mushroom	7.81	Malik et al.120
Vitrofolal E		L-DOPA		NR	NR	Mushroom	9.76	Malik et al.120
(+)-Lyoniresinol		L-DOPA		NR	NR	Mushroom	3.21	Malik et al.120
(+)-Lyoniresinol-3α-O-β-D-glucoside		L-DOPA		NR	NR	Mushroom	NA	Malik et al.120
(+)-(−)-Pinoresinol		L-DOPA		NR	NR	Mushroom	15.13	Malik et al.120
(+)-Diasyringaresinol		L-DOPA		NR	NR	Mushroom	5.61	Malik et al.120
Eleuterozyd $E_1$	Opilia amentacea	L-DOPA	Kojic acid	NR	NR	Mushroom	28	Magid et al.121
4-O-Lariciresinol-glucoside	Marrubium velutinum and Marrubium cylleneum	L-DOPA	Kojic acid	NR	NR	Mushroom	64	Myose et al.78
4′-O-Lariciresinol-glucoside		L-DOPA	Kojic acid	NR	NR	Mushroom	64	Myose et al.78
4,4′-O-Lariciresinol-bis-glucoside		L-DOPA	Kojic acid	NR	NR	Mushroom	49	Myose et al.78

NR: not reported; NA: not active