Table 22.

Structure and activity of coumarin against tyrosinase.

Structure	Name	IC50 (μM)	Ref.
	Coumarin	8100	Masamoto et al.143
	Esculetin	43/6.9	Masamoto et al.143; Li et al.144
	Umbelliferone	420	Masamoto et al.143
	Scopoletin	2600/0.2	Masamoto et al.143; Li et al.144
	Esculin	>14000	Masamoto et al.143
	Scopoline	15.9	Li et al.144
	5,7-dihydroxycoumarin-7-(6-O-β-D-apiofuranosyl-β-Dglucopyranoside)	>400	Zheng et al.145
	xeroboside	>400	Zheng et al.145
	7-[[6-O-(6-deoxy-R-L-mannopyranosyl)-β-Dglucopyranosyl]oxy]-2H-1-benzopyran-2-one	>400	Zheng et al.145
	mulberroside B	>500	Zheng et al.145
	5,7-dihydroxycoumarin-7-O-β-D-glucopyranoside	>400	Zheng et al.145
	8′-epi-cleomiscosin A	1.33	Ahmad et al.146
	Cleomiscosin A	18.69	Ahmad et al.146
	aquillochin	15.69	Ahmad et al.146
	5,6,7-trimethoxycoumarin	8.65	Ahmad et al.146
	8-O-b-Dglucopyranosyl-6-hydroxy-2-methyl-4H-1-benzopyrane-4- one	256.97	Ahmad et al.146
	3-Phenylcoumarin	>1000	Matos et al.147
	3-Thiophenylcoumarin	>1000	Matos et al.147
	5,7-Dihydroxy-3-(3-thiophenyl)coumarin	0.19	Matos et al.147
	3-(4′-Bromophenyl)-5,7-dihydroxycoumarin	1.05	Matos et al.147
	2-(1-(Coumarin-3-yl)ethylidene) hydrazinecarbothioamide	3.44	Liu et al.150
	4c	118.48	Ashraf et al.151
	4e	8.96	Ashraf et al.151
	6a	123.77	Ashraf et al.151
	6b	80.20	Ashraf et al.151