Table 2. Half-maximal inhibitory concentration (IC50) values for the C-terminal peptide, in comparison with its phosphorylated form.
The values indicated in the table were deduced from dose-response curves displayed in Figure 5B and C. The number of data points used to calculate the IC50 is indicated in parenthesis. IC50 values are expressed as mean ± s.d.
| ATP8B1-CDC50A | Inhibitory peptide | IC50 (µM) |
|---|---|---|
| ΔN42/C1174(n = 33) | C-terminal | 22.1 ± 1.2 |
| ΔN42/C1174(n = 35) | PhosphorylatedC-terminal | 377.4 ± 227 |
| ΔC1174 (n = 34) | C-terminal | 0.081 ± 0.014 |
| ΔC1174 (n = 47) | PhosphorylatedC-terminal | 1.96 ± 0.35 |