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. 2022 Apr 18;4(4):458–475. doi: 10.1038/s42255-022-00558-0

Fig. 8. Microbiome-derived formate drives CRC invasion via secreted formate.

Fig. 8

The Fn metabolism product formate promotes AhR signalling in vitro and in vivo, which results in increased Th17 cell infiltration and ALDH activity, cancer stemness and metastatic dissemination of tumour cells.