Figure 3.

Individual dolutegravir C_trough, AUC_{0–24 h}, and C_max in children weighing 3 kg to less than 20 kg taking DT or FCT

The horizontal black lines indicate geometric means per dose. The shaded area indicates concentrations below dolutegravir in-vivo EC₉₀. The dashed lines indicate published geometric mean adult reference values for 50 mg onc per day (lower lines) and twice per day (upper lines). DT=dispersible tablet. FCT=film-coated tablet. AUC_{0–24 h}=area under the concentration-time curve from 0 to 24 h. C_trough=trough concentration. C_max=maximum concentration. EC₉₀=the effective concentration at which 90% of maximal viral inhibition is achieved in a 10-day monotherapy study. *Children younger than 6 months.