Figure 3.

Plasma immune cell populations from SIV + saline and SIV + deprenyl macaques were evaluated by flow cytometry

Flow cytometry was used to examine deprenyl-mediated changes in the numbers of CD4⁺ (A) and CD8⁺ T cells (B), the ratio of CD4 to CD8 T cells (C), as well as in the percentage of monocytes that were CD14 + CD16⁺ (D) in blood. Relative to saline-treated animals, immune populations from deprenyl-treated animals showed decreased numbers of CD4⁺ T cell and CD8⁺ T cells, and a decreased percentage of proinflammatory CD14 + CD16 ⁺ monocytes. The only significant decrease was seen in the number of CD8⁺ T cells per μL of blood [B, multiple unpaired t-tests corrected for multiple comparisons using the Holm-Sidak method, t = 4.989, ∗∗p = 0.0074]