Table 1.
Values of analytes detected by Human v2.0 Multianalyte profile immunoassay in SIV-infected saline versus deprenyl-treated macaques
| Analyte (units) | Abbr. | Range in healthy animals | Day 7 SIV + Saline | Day 7 SIV + deprenyl | Day 7 Saline versus deprenyl | Day 14 SIV + Saline | Day 14 SIV + deprenyl | Day 14 Saline versus deprenyl |
|---|---|---|---|---|---|---|---|---|
| Adiponectin (ug/mL) | 6.8 - 60 | 21.25 ± 5.32 | 37.25 ± 19.43 | p = 0.3729 | 30.75 ± 13.60 | 42.75 ± 23.80 | p = 0.3729 | |
| Alpha-1-Antitrypsin (mg/mL) | AAT | 0.094 - 0.26 | 0.103 ± 0.012 | 0.128 ± 0.019 | p = 0.2376 | 0.218 ± 0.022 | 0.22 ± 0.028 | p = 0.8699 |
| Alpha-2-Macroglobulin (mg/mL) | A2Macro | 0.82 - 2.1 | 0.99 ± 0.14 | 1.02 ± 0.12 | p = 0.7210 | 1.23 ± 0.15 | 1.3 ± 0.082 | p = 0.6580 |
| Alpha-Fetoprotein (ng/mL) | AFP | 1.1-46 | 1.93 ± 1.85 | 3.18 ± 1.58 | p = 0.6350 | 4.45 ± 2.81 | 9.25 ± 6.204 | p = 0.1626 |
| Apolipoprotein(a) (ug/mL) | Lp(a) | 77-1130 | 232.5 ± 92.13 | 219.75 ± 100.06 | p = 0.9212 | 467.25 ± 176.10 | 402.25 ± 279.226 | p = 0.8525 |
| Apolipoprotein A-I (mg/mL) | Apo A-I | 0.58-2.8 | 1.60 ± 0.29 | 1.63 ± 0.50 | p = 0.9544 | 1.18 ± 0.79 | 2.10 ± 0.71 | p = 0.1007 |
| Apolipoprotein A-II (ng/mL) | Apo A-II | 198-495 | 522.00 ± 48.67 | 397.00 ± 37.90 | p = 0.1903 | 626.25 ± 169.56 | 528.00 ± 82.69 | p = 0.1903 |
| Apolipoprotein C-I (ng/mL) | Apo C-I | 103-273 | 171.25 ± 24.45 | 169.25 ± 29.05 | p = 0.9635 | 212.25 ± 87.39 | 279.75 ± 74.50 | p = 0.2612 |
| Apolipoprotein C-III (ug/mL) | Apo C-III | UN-185 | 85.33 ± 18.01 | 83.00 ± 0 .00 | p = 0.4246 | 148.50 ± 63.75 | 203.25 ± 59.06 | p = 0.2520 |
| Brain-Derived Neurotrophic Factor (ng/mL) | BDNF | UN-3.5 | 0.595 ± 0.302 | 0.113 ± 0.056 | p = 0.0262 | 0.70 ± 0.06 | 0.17 ± 0.10 | p = 0.1703 |
| C-Reactive Protein (ug/mL) | CRP | UN-0.95 | 0.051 ± 0.00 | 0.050 ± 0.007 | p = 0.8056 | 0.285 ± 0.199 | 0.0370 ± 0.000 | p = 0.0145 |
| Complement C3 (mg/mL) | C3 | 0.33-1.2 | 0.365 ± 0.051 | 0.385 ± 0.031 | p = 0.6387 | 0.703 ± 0.055 | 0.6250 ± 0.085 | p = 0.1657 |
| Factor VII (ng/mL) | 8.5-165 | 25.5 ± 11.9 | 45.0 ± 16.1 | p = 0.4775 | 154.50 ± 34.55 | 136.50 ± 27.40 | p = 0.4775 | |
| Ferritin (ng/mL) | FRTN | UN-186 | 817.5 ± 645.7 | 960.0 ± 717.7 | p = 0.9187 | 291.8 ± 199.1 | 153.0 ± 53.2 | p = 0.9187 |
| Fibrinogen (mg/mL) | 0.061-.44 | 0.102 ± 0.020 | 0.131 ± 0.053 | p = 0.4923 | 0.140 ± 0.016 | 0.125 ± 0.026 | p = 0.5817 | |
| Growth Hormone (ng/mL) | GH | 0.2-86 | 26.68 ± 21.60 | 15.28 ± 7.37 | p = 0.4673 | 2.90 ± 2.97 | 12.33 ± 7.34 | p = 0.4673 |
| Haptoglobin (mg/mL) | UN-1.6 | 0.368 ± 0.271 | 0.560 ± 0.096 | p = 0.6840 | 0.95 ± 0.509 | 0.743 ± 0.244 | p = 0.6840 | |
| Insulin (μIU/mL) | UN-24 | 11.00 ± 2.55 | 3.93 ± 1.91 | p = 0.0140 | 4.85 ± 0.55 | 4.53 ± 3.77 | p = 0.7077 | |
| Interleukin-1 receptor antagonist (pg/mL) | IL-1ra | UN-199 | 1577.5 ± 273.6 | 1977.5 ± 366.8 | p = 0.1308 | 343.0 ± 114.2 | 277.5 ± 124.8 | p = 0.7479 |
| Interleukin-6 (pg/mL) | IL-6 | UN-19 | 6.03 ± 1.38 | 29.75 ± 16.24 | p = 0.0081 | 4.40 ± 0.90 | 4.40 ± 0.00 | p = 0.9185 |
| Interleukin-8 (pg/mL) | CXCL8, IL-8 | 26-1160 | 272.75 ± 172.62 | 202.50 ± 72.24 | p = 0.8709 | 184.25 ± 135.32 | 103.75 ± 19.51 | p = 0.0181 |
| Interleukin-12 Subunit p40 (ng/mL) | IL-12p40 | UN-0.53 | 0.30 ± 0.00 | 0.22 ± 0.00 | p = 0.5316 | 0.34 ± 0.10 | 0.28 ± 0.00 | p = 0.5316 |
| Interleukin-16 (pg/mL) | IL-16 | UN-217 | 77.50 ± 3.64 | 82.00 ± 4.42 | p = 0.7347 | 90.50 ± 27.80 | 52.25 ± 14.29 | p = 0.0242 |
| Interleukin-18 (pg/mL) | IL-18 | UN-179 | 470.00 ± 165.83 | 915.25 ± 519.57 | p = 0.1750 | 771.00 ± 122.09 | 715.00 ± 204.14 | p = 0.8216 |
| Macrophage-Derived Chemokine (pg/mL) | MDC | 32-425 | 260.25 ± 94.23 | 174.25 ± 28.14 | p = 0.3126 | 399.75 ± 153.23 | 250.75 ± 82.41 | p = 0.1770 |
| Macrophage Inflammatory Protein-1 beta (pg/mL) | MIP-1β, CCL4 | 178-2150 | 690.50 ± 120.88 | 1266.25 ± 1184.30 | p = 0.6981 | 703.00 ± 109.86 | 1172.5 ± 1188.28 | p = 0.6981 |
| Matrix Metalloproteinase-2 (ng/mL) | MMP-2 | 2680-5100 | 4095.0 ± 778.38 | 4847.5 ± 1177.9 | p = 0.5982 | 5090.0 ± 354.9 | 5285.0 ± 337.9 | p = 0.8118 |
| Matrix Metalloproteinase-3 (ng/mL) | MMP-3 | 0.8-3.2 | 0.820 ± 0.186 | 1.055 ± 0.102 | p = 0.4452 | 1.675 ± 0.259 | 2.30 ± 0.648 | p = 0.1119 |
| Matrix Metalloproteinase-9 (ng/mL) | MMP-9 | UN-349 | 46.33 ± 9.53 | 41.33 ± 3.77 | p = 0.7166 | 68.50 ± 8.29 | 60.50 ± 14.84 | p = 0.6900 |
| Monocyte Chemotactic Protein 1 (pg/mL) | MCP-1, CCL2 | UN-380 | 1084.25 ± 219.04 | 918.75 ± 276.21 | p = 0.5085 | 341.75 ± 112.70 | 202.00 ± 49.56 | p = 0.5085 |
| Myeloperoxidase (ng/mL) | MPO | UN-1560 | 106.50 ± 32.23 | 98.50 ± 49.12 | p = 0.8559 | 142.25 ± 58.98 | 115.5 ± 54.20 | p = 0.7943 |
| Myoglobin (ng/mL) | 28-2400 | 442.75 ± 244.65 | 1211.0 ± 676.5 | p = 0.0625 | 413.5 ± 253.3 | 269.5 ± 135.8 | p = 0.6570 | |
| Neuron-Specific Enolase (ng/mL) | NSE | UN-1 | 0.557 ± 0.113 | 0.460 ± 0.228 | p = 0.8814 | 0.568 ± 0.284 | 0.388 ± 0.084 | p = 0.5622 |
| Plasminogen Activator Inhibitor 1 (ng/mL) | PAI-1 | 3.2-128 | 49.50 ± 10.45 | 22.75 ± 10.06 | p = 0.0084 | 16.58 ± 11.45 | 9.80 ± 2.01 | p = 0.3895 |
| Serotransferrin (mg/dL) | Transferrin | 20-360 | 25.00 ± 2.00 | 33.00 ± 4.55 | p = 0.9957 | 33.50 ± 3.28 | 34.00 ± 3.32 | p = 0.9957 |
| Serum Amyloid P-Component (ug/mL) | SAP | 0.69-6.9 | 2.90 ± 0.35 | 3.40 ± 0.78 | p = 0.4190 | 4.60 ± 0.99 | 3.03 ± 0.66 | p = 0.0430 |
| Stem Cell Factor (pg/mL) | SCF | UN-474 | 233.67 ± 26.40 | 300.50 ± 85.50 | p = 0.9844 | 415.00 ± 150.77 | 322.75 ± 67.98 | p = 0.5278 |
| T-Cell-Specific Protein RANTES (ng/mL) | RANTES, CCL5 | 0.2-16 | 4.28 ± 1.73 | 0.90 ± 0.46 | p = 0.0154 | 4.69 ± 4.40 | 1.38 ± 0.52 | p = 0.0154 |
| Thrombospondin-1 (ng/mL) | 282-38600 | 5302.5 ± 2512.7 | 1089.3 ± 539.9 | p = 0.0271 | 2743.0 ± 2450.8 | 1078.25 ± 409.45 | p = 0.2763 | |
| Tissue Inhibitor of Metalloproteinases 1 (ng/mL) | TIMP-1 | 32-151 | 96.75 ± 8.84 | 83.50 ± 9.39 | p = 0.1793 | 88.50 ± 15.11 | 66.25 ± 11.10 | p = 0.0666 |
| Transthyretin (mg/dL) | TTR | UN-13 | ND | 5.4 ± 0.00 | ND | 4.85 ± 0.75 | 7.05 ± 2.50 | p = 0.1683 |
| Tumor necrosis factor receptor 2 (ng/mL) | TNFR2 | UN-4.9 | 7.53 ± 1.93 | 8.40 ± 1.88 | p = 0.5647 | 11.90 ± 2.10 | 7.65 ± 1.19 | p = 0.0277 |
| Vascular Cell Adhesion Molecule-1 (ng/mL) | VCAM-1 | 209-389 | 555.75 ± 103.92 | 669.50 ± 67.45 | p = 0.1521 | 576.50 ± 67.77 | 495.25 ± 34.07 | p = 0.1958 |
| Vascular Endothelial Growth Factor (pg/mL) | VEGF | UN-112 | ND | 60.00 ± 0.00 | ND | 60.00 ± 16.97 | 54.00 ± 0.00 | p = 0.2136 |
| Vitamin D-Binding Protein (ug/mL) | VDBP | UN-300 | 22.00 ± 4.00 | 24.25 ± 6.02 | p = 0.2624 | 39.75 ± 4.09 | 45.75 ± 8.23 | p = 0.2743 |
| von Willebrand Factor (ug/mL) | vWF | 87-429 | 360.25 ± 59.60 | 328.50 ± 89.30 | p = 0.5729 | 205.25 ± 59.69 | 153.25 ± 42.48 | p = 0.5729 |
Values in bold were significantly different between SIV + saline and SIV + deprenyl conditions. ND; not detected, UN; undetectable.