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In vitro antiviral parameters for SARS-CoV-2 Mpro inhibitors measured in Vero E6 TMPRSS cells in the absence or presence of P-glycoprotein inhibitor CP-100356.
| Compound | EC50, μM (without CP-100356) | EC50, [95% CI], μM (with CP-100356) | CC50, μM |
|---|---|---|---|
| BBH-1 | 16.1 | 1.54 [0.82, 2.84] | >10 |
| BBH-2 | 15.4 | 0.88 [0.46, 1.66] | >10 |
| NBH-2 | 13.9 | 1.82 [0.90, 3.66] | >10 |
| PF-07321332 | 0.88 | 0.25 [0.07, 0.71] | >10 |
