REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
Antibodies and dyes for flow cytometry	This paper (Table S2)	N/A
CD16/CD32 Monoclonal Antibody, Clone 93	eBioScience	Cat#14-0161-86
Human BD Fc Block	BD Biosciences	Cat#564220
Chemicals, peptides, and recombinant proteins
Lipopolysaccharides from Escherichia coli O55:B5	Sigma Aldrich	Cat#L2637
Recombinant Murine IFN-γ	Peprotech	Cat#315-05
Recombinant Human IFN-γ	Peprotech	Cat# 300-02
Recombinant Murine IL-4	Peprotech	Cat#214-14
Recombinant Human IL-4	Peprotech	Cat# 300-02
Lymphoprep™	Stemcell technologies	Cat#07861
Percoll™	Cytiva	Cat#17-0891-01
Human M-CSF, research grade	Miltenyi	Cat#130-096-491
Phosphoric acid, 85 wt. %	Sigma Aldrich	Cat#345245
Sulfanilamide	Sigma Aldrich	Cat#S9251
N-(1-Naphtyl)ehtylene diamine dihydrochloride	Sigma Aldrich	Cat#N9125
Triton X-100	Sigma Aldrich	Cat#X100
Tris(hydroxymethyl)aminomethane	Sigma Aldrich	Cat#1083821000
cOmplete™, Mini Protease Inhibitor Cocktail	Roche	Cat#11836153001
Manganese(II) chloride tetrahydrate	Sigma Aldrich	Cat#M5005
L-arginine	Fluka	Cat#11010
Sulfuric acid, 95.0-98.0%	Fisher Scientific	Cat#15642780
α-isonitrosopropriophenone	Sigma Aldrich	Cat#I3502
Glucose GOD-PAP	Biolabo	Cat#LP80209
meta-Phosphoric acid	Sigma Aldrich	Cat#239275
Glycine	Sigma Aldrich	Cat#15527
Hydrazine hydrate	Sigma Aldrich	Cat#225819
NAD+ (free acid)	Cayman Chemicals	Cat#16077
L-Lactate Dehydrogenase (L-LDH)	Sigma Aldrich	Cat#10127876001
Agilent Seahorse XF Base Medium	Agilent	Cat#102353-100
D-(+)-Glucose solution (45%)	Sigma Aldrich	Cat#G8769
Oligomycin	Sigma Aldrich	Cat#O4876
Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone	Sigma Aldrich	Cat#C2920
Antimycin A	Sigma Aldrich	Cat#A8674
Rotenone	Sigma Aldrich	Cat#R8875
Hoechst 33342	Thermo Fisher	Cat#H3570
Saponin	Sigma Aldrich	Cat#SAE0073
Lipofermata	Cayman Chemicals	Cat#25869
Phloretin	Sigma Aldrich	Cat#P7912
Critical commercial assays
SCENITH kit	Arguello et al. (2020)	http://www.scenith.com
Foxp3 / Transcription Factor Staining Buffer Set	eBioScience	Cat#00-5523-00
PM-M01 kit	Biolog	Cat#13101
Mito-S1 kit	Biolog	Cat#14105
Experimental models: Cell lines
LCM derived from L929 Cell Line from mouse	Sigma Aldrich	L929 cells: Cat#85011425-1VL
Experimental models: Organisms/strains
C57Bl/6J	Charles River	Strain #632
Buffy coats	Sanquin	Cat# E2824R00
Software and algorithms
Gen 5™	BioTek	https://www.biotek.com/products/software-robotics-software/gen5-microplate-reader-and-imager-software/
Wave version 2.6.0.31	Agilent	https://www.agilent.com/en/product/cell-analysis/real-time-cell-metabolic-analysis/xf-software/seahorse-wave-desktop-software-740897
Flow Jo v10	TreeStar	https://www.flowjo.com
OMIQ	OMIQ	https://omiq.ai/
tSNE-CUDA	Chan et al. (2019)	https://github.com/CannyLab/tsne-cuda
Biolog Data Analysis Software version 1.7.1.58	Biolog	https://www.biolog.com/
GraphPad Prism software version 8.2.1	GraphPad Software	https://www.graphpad.com
Other
XF-96-cell culture plates and cartridges	Agilent	Cat#101085-004
RPMI 1640 Medium, no glucose	Gibco	Cat#11879020