Figure 4.

Deep characterization of the endothelial cell compartment in the BM

(A) UMAP representation of arteries (red) and sinusoids (blue) within the endothelial cell population. The right-bottom subpanel depicts the final endothelial clusters identified.

(B) Violin plot of gene expression for known markers of arteries and sinusoids cell subtypes.

(C) Violin plot of gene expression for new marker candidates separating arteries and sinusoids cell subtypes.

(D) Dot plot of the top 5 markers for each endothelial subcluster. Dot size corresponds to the proportion of cells within the group expressing each gene, and dot color corresponds to the average expression level.

(E) Selected set of gene sets derived from the gene set analysis conducted with top 50 markers per cluster (see STAR Methods).

(F) Final clustering of the endothelial cell population and the labeling assigned based on marker genes and gene set analysis. See also Figure S4 and Tables S2, S3, and S4.