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. 2022 Apr 8;25(5):104225. doi: 10.1016/j.isci.2022.104225

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© 2022 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Deep characterization of the mesenchymal cell compartment in the BM

(A) UMAP representation of mesenchymal (red) and osteolineage-primed (OLN-primed) (blue) within the mesenchymal compartment. The right-upper subpanel depicts the final mesenchymal clusters identified.

(B) Violin plot of gene expression for known markers of mesenchymal (red) and osteolineage-primed (blue) cells.

(C) Violin plot of gene expression for new marker candidates separating mesenchymal (red) and osteolineage primed (blue) cells.

(D) Dot plot of the top 5 markers for each mesenchymal subcluster. Dot size corresponds to the proportion of cells within the group expressing each gene, and dot color corresponds to the average expression level.

(E) Selected set of gene sets derived from the gene set analysis conducted with top 50 markers per cluster (see STAR Methods). (∗) transmembrane receptor protein serine/threonine kinase signaling pathway.

(F) Final clustering of the mesenchymal cell population and the annotation based on marker genes and gene set analysis. See also Figure S4 and Tables S5, S6 and S7.