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. 2022 Feb 12;13(6):1717–1740. doi: 10.1016/j.jcmgh.2022.02.005

Figure 3.

Figure 3

CD causes shifts in the colonic epithelial landscape. (A) Crypt–axis score density for NIBD and CD cells separately shows a shift toward the colonic crypt top in CD. The significance of the shift was determined using the Kolmogorov–Smirnov test (∗∗∗P < .001). (B) Mean cell abundances across NIBD and CD samples show a significant increase in CA1+ colonocytes in CD. Dots show abundance values of individual samples. (C) Mean cell abundances for either CA1+ early or late colonocyte clusters across NIBD and CD samples shows a significant increase only in the CA1+ late colonocytes. Dots show abundances of individual samples. Abundances of other clusters are not shown. (D) Mean ratio of absorptive to secretory cells across NIBD and CD samples. (E) Mean ratio of EEC to mature goblet cells across NIBD and CD samples shows a significant shift in the secretory lineage toward mature goblet cells in CD. (F) Mean ratio of immature goblet to mature goblet across NIBD and CD samples show a shift toward mature goblet cells in CD. If not indicated, P values are calculated by a Student t test. ∗P < .05; ∗∗P < .01.