Figure 4.

Effect of CD within cell types. (A) Number of significant differentially expressed genes in CD vs NIBD. Clusters are shown on the x-axis followed by the number of cells within the cluster in parenthetical notation and the number of differentially expressed genes is shown on the y-axis. (B) Differentially expressed genes for 3 clusters: CA1+ late colonocyte, CEACAM7+ colonocyte, and mature goblet. Log₂ fold change is shown on the x-axis and the adjusted P value is shown on the y-axis. Mean expression of (C) SLC26A2 and CA2, (D) AQP8, (E) CD177 and LYPD8, and (F) CLDN4 across clusters for NIBD and CD samples shows the specificity of expression and differential expression within clusters. P values were calculated by the Wilcoxon rank-sum test. ∗∗∗Adjusted P < .001.