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. 2022 Feb 12;13(6):1717–1740. doi: 10.1016/j.jcmgh.2022.02.005

Figure 6.

Figure 6

Transposable elements define cell types and are dysregulated in CD. (A) Uniform Manifold Approximation and Projection (UMAP) of epithelial cell clustering after TE inclusion maintains structure. Mean expression of (B) MER11A and (D) MER11C across clusters for NIBD and CD samples shows the specificity of expression within clusters. UMAP overlain with the normalized expression of TE markers (C) MER11A or (E) MER11C further confirms cluster specificity. (F) Mean expression for L1PA10 in the goblet cluster, and (G) UMAP of the goblet cluster with expression of L1PA10 overlain, separated by NIBD/CD. (H) Mean expression for SVA-D in the secretory progenitor cluster, and (I) UMAP of the secretory progenitor cluster with expression of SVA-D overlain, separated by NIBD/CD. P values were calculated by the Wilcoxon rank-sum test. #Adjusted P < .1, ∗adjusted P < .05.