Table 2.

Retinal layer thickness at the fovea, and at the parafovea 1000 microns nasal and temporal to the fovea (Mean ± SD). P value calculated using Student’s T-Test. Only right eyes assessed.

Retinal Layer	Down Syndrome Cohort	Normative Data (μm)	P value	Significant after Bonferroni correction
Fovea
Foveal RNFL	6.0 ± 7.1	0.0 ± 0.0	0.019
Foveal GCL	31.9 ± 25.1	0.1 ± 0.5	0.002	*
Foveal IPL	30.8 ± 11.7	3.4 ± 5.2	0.017
Foveal INL	20.5 ± 11.0	1.0 ± 2.1	<0.001	*
Foveal OPL	18.5 ± 12.1	4.6 ± 4.9	0.009
Foveal ONL	112.8 ± 17.1	99.5 ± 11.9	0.053
Foveal IS	36.0 ± 8.5	33.8 ± 4.0	0.598
Foveal OS	35.8 ± 4.9	32.4 ± 6.4	0.216
Foveal RPE	24.7 ± 9.7	17.5 ± 3.9	0.058
Foveal Retinal Thickness	255.1 ± 66.1	206.6 ± 13.6	0.036
Nasal parafovea
Parafoveal RNFL	33.4 ± 10.8	12.6 ± 3.5	<0.0001	*
Parafoveal GCL	101.9 ± 25.4	53.7 ± 9.6	<0.0001	*
Parafoveal IPL	53.7 ± 6.6	44.6 ± 11.6	0.1892
Parafoveal INL	55.5 ± 7.9	49.4 ± 7.7	0.0308
Parafoveal OPL	44.2 ± 10.0	34.9 ± 16.2	0.0917
Parafoveal ONL	43.8 ± 18.2	68.4 ± 18.6	0.0004	*
Parafoveal IS	37.9 ± 9.6	27.8 ± 3.9	0.0001	*
Parafoveal OS	31.1 ± 8.5	14.6 ± 4.7	<0.0001	*
Parafoveal RPE	18.6 ± 8.4	18.4 ± 3.9	0.8973
Parafoveal Retinal Thickness	378.4 ± 8.3	342.3 ± 14.5	0.0001	*
Temporal parafovea
Parafoveal RNFL	22.8 ± 9.5	6.6 ± 2.8	<0.0001	*
Parafoveal GCL	90.7 ± 24.9	48.0 ± 11.0	0.0001	*
Parafoveal IPL	43.3 ± 21.6	42.3 ± 10.9	0.8819
Parafoveal INL	50.9 ± 7.5	46.0 ± 6.4	0.061
Parafoveal OPL	35.7 ± 17.1	27.6 ± 10.5	0.0802
Parafoveal ONL	70.1 ± 26.6	73.8 ± 14.3	0.6275
Parafoveal IS	32.5 ± 9.2	29.6 ± 3.6	0.1674
Parafoveal OS	32.2 ± 10.1	14.0 ± 5.0	<0.0001	*
Parafoveal RPE	22.5 ± 4.4	17.7 ± 4.0	0.0091
Parafoveal Retinal Thickness	361.5 ± 26.9	326.1 ± 13.9	0.0002	*