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. 2022 Apr 27;12:6902. doi: 10.1038/s41598-022-10914-5

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© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Among all investigated HERVs, certain HERV superfamilies demonstrated high degrees of dysregulation in the A172, M059J, and H4 cell lines in (A). (B) demonstrates the relative expression of highly dysregulated loci in each cell line and correlates HERV expression in each cell line Namely, A172 cell lines, which demonstrate the highest overall HERV expression, are most significantly correlated with each other, but have almost no association with other investigated cell lines.