Table 3.
Univariable and multivariable analysis of factors potentially contributing to a significant weight loss of > 5% during CRT/BRT and to TF dependency
| Significant weight loss of > 5% during CRT/BRT | TF dependency | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Univariable analysis | Multivariable analysis* | Univariable analysis | Multivariable analysis* | |||||||||||||
| OR | CI-95% | p Value | OR | CI-95% | p Value | OR | CI-95% | p Value | OR | CI-95% | p Value | |||||
| Lower | Upper | Lower | Upper | Lower | Upper | Lower | Upper | |||||||||
| Age | 1.018 | 0.960 | 1.078 | 0.556 | 0.980 | 0.922 | 1.041 | 0.509 | ||||||||
| Sex (male vs. female) | 1.265 | 0.476 | 3.363 | 0.637 | 0.776 | 0.281 | 2.141 | 0.624 | ||||||||
| Smoking | 0.848 | 0.210 | 3.434 | 0.818 | 0.759 | 0.175 | 3.297 | 0.713 | ||||||||
| Alcohol | 1.968 | 0.781 | 4.956 | 0.151 | 0.982 | 0.386 | 2.501 | 0.970 | ||||||||
| BMI | 1.113 | 1.003 | 1.236 | 0.044 | 1.130 | 1.011 | 1.262 | 0.031 | 0.987 | 0.895 | 1.089 | 0.799 | ||||
| Weight loss prior to CRT/BRT | 0.941 | 0.823 | 1.075 | 0.370 | 1.187 | 1.001 | 1.407 | 0.049 | ||||||||
| Dysphagia at start RT (CTCAE grade 2 vs. 0 or 1) | 0.521 | 0.185 | 1.468 | 0.217 | 1.256 | 0.435 | 3.627 | 0.673 | ||||||||
| WHO PS (1 or 2 vs. 0) | 0.597 | 0.221 | 1.611 | 0.309 | 1.689 | 0.627 | 4.547 | 0.300 | ||||||||
| CCI (≥ 4 vs. < 4) | 0.738 | 0.205 | 2.659 | 0.642 | 0.732 | 0.202 | 2.650 | 0.634 | ||||||||
| T3 or T4 vs. T0, T1 or T2 | 0.599 | 0.239 | 1.498 | 0.273 | 1.765 | 0.696 | 4.476 | 0.232 | ||||||||
| N2 or N3 vs. N0 or N1 | 1.821 | 0.578 | 5.739 | 0.306 | 1.056 | 0.333 | 3.342 | 0.927 | ||||||||
| p16 + vs. p16- | 1.579 | 0.631 | 3.948 | 0.329 | 0.487 | 0.185 | 1.283 | 0.145 | ||||||||
| Edentulous vs. dentate | 0.536 | 0.197 | 1.462 | 0.223 | 0.892 | 0.325 | 2.447 | 0.825 | ||||||||
| Decrease in Eichner Index (ABC) due to tooth extractions prior to CRT/BRT (binary) | 1.179 | 0.291 | 4.771 | 0.818 | 0.465 | 0.114 | 1.894 | 0.285 | ||||||||
| Tooth extractions (yes vs. no) | 2.928 | 1.094 | 7.834 | 0.032 | 3.360 | 1.185 | 9.529 | 0.023 | 0.756 | 0.283 | 2.019 | 0.577 | ||||
| Tooth extractions and additional interventions (yes vs. no) | 2.435 | 0.877 | 6.756 | 0.087 | 0.484 | 0.165 | 1.425 | 0.188 | ||||||||
| Number of removed teeth | 1.047 | 0.961 | 1.140 | 0.291 | 0.995 | 0.917 | 1.080 | 0.909 | ||||||||
| Loss of OU due to tooth extractions prior to CRT/BRT | 0.867 | 0.687 | 1.095 | 0.232 | 1.125 | 0.877 | 1.445 | 0.354 | ||||||||
| Cetuximab vs. cisplatin (ref) | 1.024 | 0.375 | 2.795 | 0.963 | 0.355 | 0.127 | 0.995 | 0.049 | 0.226 | 0.070 | 0.731 | 0.013 | ||||
| RT dose to contralateral parotid gland | 0.975 | 0.925 | 1.028 | 0.347 | 1.018 | 0.964 | 1.075 | 0.524 | ||||||||
| RT dose to contralateral submandibular gland | 1.013 | 0.973 | 1.056 | 0.523 | 1.048 | 1.001 | 1.096 | 0.044 | 1.067 | 1.013 | 1.124 | 0.015 | ||||
| RT dose to superior PCM | 1.000 | 0.954 | 1.048 | 0.995 | 1.013 | 0.966 | 1.063 | 0.584 | ||||||||
| RT dose to median PCM | 1.006 | 0.941 | 1.075 | 0.868 | 1.040 | 0.970 | 1.115 | 0.272 | ||||||||
| RT dose to inferior PCM | 1.002 | 0.956 | 1.050 | 0.938 | 1.044 | 0.990 | 1.102 | 0.112 | ||||||||
| RT dose to oral cavity | 0.992 | 0.950 | 1.037 | 0.737 | 1.031 | 0.983 | 1.081 | 0.211 | ||||||||
| RT dose to cricopharyngeus muscle | 0.974 | 0.911 | 1.040 | 0.428 | 1.088 | 1.010 | 1.173 | 0.026 | ||||||||
| RT dose to cervical esophagus | 0.952 | 0.904 | 1.002 | 0.060 | 1.044 | 0.995 | 1.096 | 0.077 | ||||||||
| TF use | 0733 | 0.292 | 1.841 | 0.508 | ||||||||||||
BMI body mass index, CCI Charlson comorbidity index, CRT/BRT chemoradiotherapy or bioradiotherapy, WHO PS World Health Organization performance status, OU occlusal units, PCM pharyngeal constrictor muscles, RT radiotherapy, TF tube feeding
Boldface values denote statistical significance at the p < 0.05 level
*Step-backward analysis of all variables with p < 0.05 in univariable analysis