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. 2021 Oct 28;163(8):1479–1488. doi: 10.1097/j.pain.0000000000002529

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Copyright © 2021 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the International Association for the Study of Pain.

This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

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Figure 4. — Paclitaxel decreases capsaicin-induced analgesia for mechanical hyperalgesia in mice with chronic constriction injury of the infraorbital nerve (ION-CCI). Changes in mechanical sensitivity in the contralateral (A and C) or ipsilateral (B and D) side of skin behind the vibrissa pad within the infraorbital territory (V2) after a sham or ION-CCI procedure. Paclitaxel (PAC; 40 µg in 20 µL) or vehicle (Veh) alone (A and B) or a combination of capsaicin (Cap; 10 µg) and PAC or Veh (C and D) were injected 2 weeks after surgery. (A–B) N = 6 in sham/PAC (3 males and 3 females) and N = 5 in the other groups (3 males and 2 females). (C–D) N = 6 in each group (3 males and 3 females/group). Two-way repeated measures ANOVA followed by the Sidak posttest; ***P < 0.001 (vs. CCI/Cap/Veh). ANOVA, analysis of variance.