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. 2022 Apr 14;10:860985. doi: 10.3389/fchem.2022.860985

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Copyright © 2022 Zheng, Zhang, Li, He, Wei, Dang, Nie and Guo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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FGFR1 kinase domain structure (PDB: 4UWY). Basic secondary structures and critical regions described in this review are highlighted in (A). The critical DFG, HRD motif and molecular brake are highlighted by close-up in (B–D), respectively.