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(A) Discovery of pyrido [1,2-a] pyrimidinone derivatives as non-covalent pan-FGFR inhibitor. (B) Discovery of 1H-Pyrazolo [3,4-b]pyridine derivatives from AZD4547 and summary of its interactions with FGFR1 ATP binding site. Hydrophobic interactions are outlined by hashed brown arc (PDB: 4V05). (C) Summary of CH5183284 and designed fragment.
