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. 2022 Apr 14;12:873020. doi: 10.3389/fonc.2022.873020

Figure 2.

Figure 2

RBM15B promotes HCC cell proliferation and metastasis. (A) The expression of RBM15B in HCC cell lines with shRNA-mediated knockdown. (B, C) CCK-8 and colony formation assays showing the proliferation ability of HCC cell lines (n=6). (D, E) Scratch wound healing motility assay showing cell migration in HCC cell lines (n=3). (E) Transwell Matrigel invasion assay showing cell invasion in HCC cell lines (n=3). (F) Tumor growth curves of xenograft models established from control or stable RBM15B knockdown HCC-LM3 cells (n=5). (G) RBM15B and Ki-67 expression was determined by IHC analysis. (H) Metastasis in the lungs of nude mice injected with control or stable RBM15B knockdown HCC cells (n=5). *p < 0.05; **p < 0.01; ***p < 0.001. ns means no significant difference.