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. 2022 Apr 14;12:873020. doi: 10.3389/fonc.2022.873020

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Copyright © 2022 Tan, Xia, Zhang, Xu, Liu, Guo and Liu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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RBM15B increases HCC resistance to sorafenib. (A) The IC50 values in different cell lines were shown. (B) Human HCC cell lines were treated with sorafenib, and the protein expression of RBM15B was assayed by qRT-PCR and Western blotting. (C) The effect of RBM15B knockdown on sorafenib resistance. (D) The effect of RBM15B overexpression on sorafenib resistance. (E) CCK-8 assay results showing the proliferation ability of HCC cells. *p < 0.05; **p < 0.01; ***p < 0.001.