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. 2022 Apr 14;12:873020. doi: 10.3389/fonc.2022.873020

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Copyright © 2022 Tan, Xia, Zhang, Xu, Liu, Guo and Liu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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TRAM2 is an important downstream target of RBM15B. (A) Detection of TRAM2 mRNA expression in different groups of HCC cell lines. (B, C) CCK-8 and colony formation assay results showing the proliferation ability of HCC cell lines. (D) Scratch wound healing motility assay results showing the migration of HCC cell lines. (E) Transwell Matrigel invasion assay showing the invasion of HCC cell lines. (F) Assessment of the size and weight of the dissected tumors after 5 weeks. (G) TRAM2 and Ki-67 expression was determined by IHC analysis. (H) Metastasis in the lungs of nude mice injected with different HCC cells. *p < 0.05; **p < 0.01; ***p < 0.001.