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. 2022 Apr 14;12:873020. doi: 10.3389/fonc.2022.873020

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Copyright © 2022 Tan, Xia, Zhang, Xu, Liu, Guo and Liu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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RBM15B is directly regulated by the transcription factor YY1. (A) Joint analysis of multiple databases predicted YY1 as a transcription factor of RBM15B. (B) After YY1 knockdown, RBM15B mRNA and protein levels were significantly reduced. (C) Pearson correlation analysis of RBM15B and YY1 in the TCGA-LIHC dataset and HCC tissue samples. (D) ChIP results showed that YY1 binds to RBM15B. (E) YY1 binding sites in the WT and MUT RBM15B promoters. Dual-luciferase reporter assays showed that YY1 acts on the RBM15B promoter region. (F) Schematic diagram of the RBM15B signaling pathway. *p < 0.05; **p < 0.01; ***p < 0.001. ns means no significant difference.