Table 3.
Source tracing of autochthonous transmission of Dengue in Zhejiang Province.
| Most likely strain identified through BLAST* | Epidemiological evidence | |||
|---|---|---|---|---|
| Autochthonous transmission† | Accession number | Location (year) | Identity (%) | |
| Cixi 2004 |
KY586409 | Thailand (2004) | 99.06–99.12 | A local man returned from Thailand on 18 July 2004. Six days later, he had fever and fatigue. His serum was tested positive for anti-dengue IgG in October. |
| Yiwu 2009 |
HM466964 | GD (2009) | 99.86 | _____ |
| KT187285 | Cape Verde (2009) | 99.66 | ||
| KT187281 | Togo (2009) | 99.53 | ||
| Shaoxing 2015 |
MG895131 | Singapore (2015) | 99.93 | _____ |
| MG895091 | Maldives (2015) | 99.93 | ||
| Ningbo 2015 |
MG895131 | Singapore (2015) | 99.93 | _____ |
| MG895091 | Maldives (2015) | 99.87 | ||
| KU504492 | Shaoxing, ZJ (2015) | 99.87 | ||
| Xiaoshan 2015 |
MG894868 | Philippine (2015) | 99.73 | Only one male indigenous case was reported. He returned from Philippines with his wife on 23 October. His wife was confirmed as having Dengue on 5 November. The husband developed dengue symptoms on 16 November and tested positive for DENV RNA on 19 November. |
| Huangyan 2016 |
MG894928 | Malaysia (2016) | 99.87–100 | _____ |
| MK566212 | GD (2016) | 99.86–100 | ||
| MG894926 | Thailand (2016) | 99.80–99.93 | ||
| MF314188 | Singapore (2016) | 99.73–99.87 | ||
| Wenling 2017(Sep) | MH594882 | India (2017) | 99.39 | The husband of one of the indigenous cases returned from India in the mid-August and his serum tested positive for anti-dengue IgG. |
| Wenling 2017 (Oct) |
MK566227 | GD (2017) | 100 | _____ |
| MK466341 | YN (2017) | 99.60 | ||
| Hangzhou 2017(a) |
MH827547 | Malaysia (2017) | 99.80–99.93 | _____ |
| MK587782 | GD (2017) | 99.66–99.93 | ||
| Hangzhou 2017(b) |
MK564480 | GD 2016 |
99.66–99.80 | _____ |
| MG895168 | Thailand 2016 |
99.66–99.80 | ||
| MH827546 | Thailand (2017) | 99.53–99.66 | ||
| Hangzhou 2017(c) |
MG895150 | Thailand (2016) | 99.53–99.66 | _____ |
| MG895121 | Viet Nam (2015) | 99.46–99.60 | ||
| Dongyang 2017 |
MH110734 | Hangzhou, ZJ (2017) | 100 | _____ |
| Pujiang 2017 |
MH110734 | Hangzhou, ZJ (2017) | 100 | _____ |
| Haishu 2018 |
MG894863 | Myanmar (2015) | 99.53–99.66 | _____ |
| MG564080 | Thailand (2015) | 99.39–99.53 | ||
*
The most likely strains were those with the highest percent identity and isolated in the same year or 3 years before autochthonous transmission was identified in Zhejiang Province.
†
The sequence of autochthonous transmission at Yongjia, and Lucheng of Wenzhou in 2014 was unavailable. The sequence of autochthonous transmission in Zhejiang Province in 2018, except Haishu of Ningbo, was unavailable.
BLAST, Basic Local Alignment Search Tool; DENV, dengue virus; GD, Guangdong Province of China; ZJ, Zhejiang Province of China; YN, Yunnan Province of China.