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. 2022 Apr 14;13:874176. doi: 10.3389/fphar.2022.874176

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Copyright © 2022 Jacobsson, Golparian, Oxelbark, Franceschi, Brown, Louie, Drusano and Unemo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Growth curves of the total population of the zoliflodacin-resistant Neisseria gonorrhoeae SE600/18-D429N mutant (containing the GyrB S467N amino acid substitution plus an in vitro selected D429N substitution), in the dose-range Hollow Fiber Infection Model experiment simulating a zoliflodacin oral fractionated dose of 4 g (2 g given at 0 and 12 h) (A), 6 g (3 g given at 0 and 12 h) (B), and 8 g (4 g given at 0 and 12 h) (C) over 24 h and followed for 7 days are shown (black solid lines). The total growth of population with increased resistance (red lines) on the zoliflodacin-containing plates (2 × MIC) and total growth of the untreated control (C; black dashed line) are also shown for each treatment.