TABLE 2.
Mean, median and standard deviation of the parameter values for the Hollow Fiber Infection Model study with the N. gonorrhoeae clinical SE600/18 strain with a pre-existing GyrB S467N amino acid substitution.
| Parameter | Mean | Median | Standard deviation |
|---|---|---|---|
| Vc (L) | 1073 | 99.03 | 1050 |
| CL (L/hr) | 116.3 | 13.11 | 107.2 |
| Kg-s (hr−1) | 0.68 | 0.117 | 0.591 |
| Kg-r (hr−1) | 0.088 | 0.066 | 0.050 |
| Kkill-s (hr−1) | 9.087 | 5.218 | 4.065 |
| Kkill-r (hr−1) | 1.820 | 0.520 | 1.759 |
| C50-s (mg/L) | 0.724 | 0.134 | 0.670 |
| C50-r (mg/L) | 2.527 | 1.274 | 1.802 |
| Hs (—) | 4.202 | 3.191 | 2.350 |
| Hr (—) | 13.86 | 5.663 | 12.78 |
| POPMAX (CFU/ml) | 0.261 × 1011 | 0.109 × 1011 | 0.337 × 1011 |
| IC2 (CFU/ml) | 8.789 × 105 | 1.066 × 105 | 9.209 × 105 |
| IC3 (CFU/ml) | 5.012 | 3.059 | 3.769 |
Vc, apparent volume of the central compartment; CL, clearance; Kg-s and Kg-r, rate constants of growth for the susceptible and resistant population, respectively; Kkill-s and Kkill-r, rate constants of kill for the susceptible and resistant population, respectively; C50-s and C50-r, concentrations of zoliflodacin at which the kill rate is half maximal for the susceptible and resistant population, respectively; Hs and Hr, Hill’s constants for the susceptible and resistant populations, respectively (unitless); POPMAX, maximal population size; CFU, colony forming units; IC2 and IC3, sizes of the total and resistant populations, respectively, at therapy initiation.