Table 1.

Cardiac burden of systemic diseases.

Disease	Prevalence	Percentage Of Heart Affection	Risk Of Cardiac Death
Hypertension	31.5% (low-income countries) 28.5% (high-income countries)7	Accounts for 50% of ischemic heart disease cases8	13% of total deaths worldwide8
Obesity	13% in 18 yo and older9	40% increased risk for CVD with every 5kg/m2 BMI increase10
Diabetes mellitus	8.5%11	Every 1% increase in HbA1c corresponds with 30% increased risk of HF12	65%13
Radiation induced cardiomyopathy	-	0.5-37% in breast cancer (dose-dependent).14 49.5-54.6% in Hodgkin lymphoma.14	1.5 to 3 fold increased fatal myocardial infarction risk compared to unirradiated Hodgkin lymphoma patients.15 62% increased cardiac deaths among breast cancer survivors 16
Chemotherapy-related cardiomyopathy	-	anthracyclines: 5-48% (dose dependent).17 trastazumab: 7-34%18	68% 5-year survival rate with cardiac affection as leading cause19
Rheumatic heart disease20	30 million people globally	60%	305,000 deaths/year
Systemic Lupus Erythematosis	20 to 150 cases per 100,000 in US21	50%22	32%23
Rheumatoid arthritis	0.2–1.0%24	48% increased risk of developing CVD events25	39.6%26