Table 4.

Total and specific reactions in vaccination group after dose 1 vs. after dose 2.

	No. of studies	RR (95% CI)	I2	P -value
Overall
Total adverse reactions	3	1.00 [0.99, 1.02]	90	>0.05
Local adverse reactions	3	1.02 [1.00, 1.04]	82	<0.05*
Systemic adverse reactions	3	0.83 [0.81, 0.86]	96	<0.05*
Overall	6	0.73 [0.71, 0.74]	97	>0.05
Local pain	6	1.02 [1.00, 1.04]	73	P = 0.05
Erythema/ Redness	5	0.70 [0.62, 0.79]	0	<0.05*
Induration	1	2.00 [0.18, 21.71]	Not applicable	>0.05
Pruritus/ Itch	3	1.15 [0.39, 3.41]	0	>0.05
Swelling	6	0.79 [0.70, 0.89]	0	<0.05*
Axillary Swelling	1	1.11 [1.00, 1.23]	Not applicable	P = 0.05
Fever	6	0.44 [0.37, 0.53]	95	<0.05*
Cough	3	1.76 [0.99, 3.12]	0	P = 0.05
Oropharyngeal pain	1	3.00 [0.32, 28.35]	Not applicable	>0.05
Headache	6	0.65 [0.62, 0.69]	65	<0.05*
Fatigue	6	0.72 [0.69, 0.76]	39	<0.05*
Myalgia	6	0.59 [0.55, 0.64]	39	<0.05*
Arthralgia	4	0.52 [0.47, 0.58]	0	<0.05*
Nausea/ vomiting	1	0.47 [0.42, 0.54]	Not applicable	<0.05*
Nausea	3	1.24 [0.49, 3.11]	0	>0.05
Vomiting	5	1.26 [0.58, 2.78]	0	>0.05
Diarrhea	4	1.45 [0.72, 2.94]	0	>0.05
Anorexia	2	1.81 [0.68, 4.83]	32	>0.05
Chills	3	0.44 [0.40, 0.48]	41	<0.05*
Pruritus (systemic adverse reaction)	1	3.00 [0.12, 72.77]	Not applicable	>0.05
Acute allergic reaction/ Hypersensitivity	1	0.33 [0.01, 8.13]	Not applicable	>0.05
Abnormal skin and mucosa	1	2.92 [0.31, 28.00]	Not applicable	>0.05
Dysphagia	1	0.33 [0.01, 8.09]	Not applicable	>0.05

^*P < 0.05.