Table 5.
Adverse reactions among vaccination group vs. control group.
| No. of studies | RR (95% CI) | I2 | P -value | ||
|---|---|---|---|---|---|
| Total adverse reactions | |||||
| After dose 1 | Overall | 3 | 1.49 [1.43, 1.55] | 70 | <0.05* |
| mRNA vaccine | 1 | 1.47 [1.41, 1.54] | Not applicable | <0.05* | |
| Inactivated vaccine | 1 | 1.27 [0.76, 2.13] | Not applicable | >0.05 | |
| Vectored vaccine | 1 | 3.44 [1.78, 6.65] | Not applicable | <0.05* | |
| After dose 2 | Overall | 3 | 1.76 [1.67, 1.85] | 60 | <0.05* |
| mRNA vaccine | 1 | 1.74 [1.66, 1.83] | Not applicable | <0.05* | |
| Inactivated vaccine | 1 | 1.83 [0.90, 3.72] | Not applicable | >0.05 | |
| Vectored vaccine | 1 | 8.25 [2.06, 33.00] | Not applicable | <0.05* | |
| After dose 3 | Overall | 0 | / | / | / |
| mRNA vaccine | 0 | / | / | / | |
| Inactivated vaccine | 0 | / | / | / | |
| Vectored vaccine | 0 | / | / | / | |
| Local adverse reactions | |||||
| After dose 1 | Overall | 3 | 2.60 [2.42, 2.80] | 47 | <0.05* |
| mRNA vaccine | 1 | 2.56 [2.38, 2.76] | Not applicable | <0.05* | |
| Inactivated vaccine | 1 | 6.34 [1.54, 26.10] | Not applicable | <0.05* | |
| Vectored vaccine | 1 | 6.00 [1.94, 18.53] | Not applicable | <0.05* | |
| After dose 2 | Overall | 3 | 2.89 [2.67, 3.14] | 8 | <0.05* |
| mRNA vaccine | 1 | 2.86 [2.64, 3.10] | Not applicable | <0.05* | |
| Inactivated vaccine | 1 | 4.29 [1.03, 17.96] | Not applicable | P=0.05 | |
| Vectored vaccine | 1 | 19.69 [1.21, 319.62] | Not applicable | <0.05* | |
| After dose 3 | Overall | 1 | 1.86 [0.55, 6.30] | Not applicable | >0.05 |
| mRNA vaccine | 0 | / | / | / | |
| Inactivated vaccine | 1 | 1.86 [0.55, 6.30] | Not applicable | >0.05 | |
| Vectored vaccine | 0 | / | / | / | |
| Systemic adverse reactions | |||||
| After dose 1 | Overall | 3 | 1.26 [1.19, 1.33] | 68 | <0.05* |
| mRNA vaccine | 1 | 1.23 [1.17, 1.31] | Not applicable | <0.05* | |
| Inactivated vaccine | 1 | 1.32 [0.87, 2.00] | Not applicable | >0.05 | |
| Vectored vaccine | 1 | 3.70 [1.55, 8.83] | Not applicable | <0.05* | |
| After dose 2 | Overall | 3 | 1.88 [1.77, 2.01] | 29 | <0.05* |
| mRNA vaccine | 1 | 1.87 [1.76, 1.99] | Not applicable | <0.05* | |
| Inactivated vaccine | 1 | 1.61 [0.76, 3.40] | Not applicable | >0.05 | |
| Vectored vaccine | 1 | 6.00 [1.48, 24.38] | Not applicable | <0.05* | |
| After dose 3 | Overall | 1 | 2.30 [0.69, 7.64] | Not applicable | >0.05 |
| mRNA vaccine | 0 | / | / | / | |
| Inactivated vaccine | 1 | 2.30 [0.69, 7.64] | Not applicable | >0.05 | |
| Vectored vaccine | 0 | / | / | / | |
*
P < 0.05.