TABLE 5.

SCR group-based dosing regimen simulations^a

SCR group (mg/dL) and dosing regimen	AUC24	AUC24 >400, %	Trough	Trough <20, %	P value (AUC and trough), %
SCR < 0.25
10 mg/kg q6h	279.8 ± 73.5	6.7	7.6 ± 2.7	100	6.7
12 mg/kg q6h	335.4 ± 88	22.5	9.1 ± 3.3	100	22.5
14 mg/kg q6h	390.3 ± 103.8	42.6	10.6 ± 3.8	99.1	41.7
15 mg/kg q6h	420.7 ± 110.4	52.9	11.4 ± 4	96.5	49.4
15 mg/kg q8h	316.7 ± 84.5	16.2	7.2 ± 3.2	99.9	16.1
20 mg/kg q6h	566.6 ± 150.8	88.9	15.4 ± 5.6	78.9	67.8
20 mg/kg q8h	421.88 ± 111.2	52.4	9.6 ± 4.2	98.5	50.9
20 mg/kg q12h	280.2 ± 73.3	6.3	4.3 ± 2.7	100	6.3
25 mg/kg q6h	706.7 ± 199.5	96.9	19.1 ± 7.3	58.1	55
25 mg/kg q8h	529.3 ± 142.6	82.1	12.1 ± 5.5	90.6	72.7
25 mg/kg q12h	352.7 ± 94.4	27.5	5.5 ± 3.3	99.9	27.4
0.25 < SCR < 0.5
10 mg/kg q6h	445.5 ± 123.9	59.2	13 ± 3.7	96.2	55.4
10 mg/kg q8h	337.9 ± 100.7	23	9.2 ± 3.4	99.8	22.8
12 mg/kg q6h	540.5 ± 146.5	84.7	15.8 ± 4.4	82.8	67.5
12 mg/kg q8h	393.1 ± 109.6	40.4	10.7 ± 3.7	98.5	38.9
14 mg/kg q6h	619.6 ± 184.1	92.5	18.1 ± 5.4	66.4	58.9
14 mg/kg q8h	465.6 ± 131.9	65.7	12.7 ± 4.5	93.6	59.3
14 mg/kg q12h	310 ± 87.6	14.4	6.9 ± 3.3	100	14.4
15 mg/kg q6h	668.4 ± 187.8	96.2	19.5 ± 5.7	55.9	52.1
15 mg/kg q8h	500.6 ± 142.7	74.3	13.7 ± 4.8	88.9	63.2
15 mg/kg q12h	334.4 ± 96.2	21.6	7.5 ± 3.6	99.9	21.5
20 mg/kg q6h	888.4 ± 263.2	99.7	25.9 ± 8	24.9	25.2
20 mg/kg q8h	666.9 ± 190.3	95.7	18.2 ± 6.5	64.5	60.2
20 mg/kg q12h	445.5 ± 130.2	59.2	10 ± 4.7	96.4	55.6
25 mg/kg q8h	837.8 ± 246.3	99.6	22.9 ± 8.4	39.5	39.1
25 mg/kg q12h	558.5 ± 165.6	82.9	12.3 ± 6	88.5	71.4
30 mg/kg q12h	668.2 ± 185.81	96.2	14.9 ± 6.9	79	75.2
0.5 < SCR ≤1
10 mg/kg q6h	808.2 ± 246.2	99.3	21.7 ± 4.9	38.3	37.6
10 mg/kg q8h	606.6 ± 172.1	90.5	17 ± 4.3	75	65.5
10 mg/kg q12h	405.2 ± 113.2	46.8	11 ± 3.6	99	45.8
12 mg/kg q6h	976.2 ± 282	99.9	26.2 ± 5.8	13.3	13.2
12 mg/kg q8h	728.5 ± 208.7	96.5	20.4 ± 5.2	48.7	45.2
12 mg/kg q12h	485.9 ± 139.7	69.8	13.3 ± 4.3	92.9	62.7
14 mg/kg q12h	563.5 ± 162.9	85.3	15.4 ± 5.1	82.9	68.2
15 mg/kg q12h	605.7 ± 175.6	89.9	16.5 ± 5.5	74	63.9
30 mg/kg q24h	607.4 ± 174.5	91.7	12.1 ± 6.3	88.4	80.1
SCR > 1
10 mg/kg q6h	1,357.7 ± 367.1	100	29.4 ± 5.7	1.7	1.7
10 mg/kg q8h	1,007.7 ± 258	100	24.7 ± 4.9	17	17
10 mg/kg q12h	685.2 ± 171.6	97.6	18.6 ± 4.1	64.5	62.1
12 mg/kg q12h	815.9 ± 220.5	99.4	22.2 ± 5.3	35.1	34.5
15 mg/kg q24h	508.8 ± 130.8	79.2	13 ± 4.5	92.2	71.4
20 mg/kg q24h	674.3 ± 182.1	96.1	17.2 ± 6.2	69.5	65.6
30 mg/kg q24h	1,019.5 ± 275.1	100	26.2 ± 9.5	27.7	27.7

^aGrey shading highlights the dosing regimens which achieved highest PTA for both AUC and trough in each SCR group.