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. 2022 Apr 14;13:842653. doi: 10.3389/fimmu.2022.842653

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Copyright © 2022 Olingy, Alimadadi, Araujo, Barry, Gutierrez, Werbin, Arriola, Patel, Ottensmeier, Dinh and Hedrick

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Specific monocyte subsets are associated with responsiveness to anti-PD-1 therapy in patients with NSCLC. (A) UMAP from Figure 2A split amongst NR versus R to anti-PD-1 treatment. Responders displayed increased numbers of cMo_CD33^hi (gold) and nMo_CD9⁺ (dark blue) cells, yet reduced numbers of cMo_CD33^lo (aqua) cells. (B) Frequencies of each monocyte cluster in PBMCs from NR versus R based on data from (A). (C) Boxplots indicating statistically significant changes in cMo_CD33^hi, nMo_CD9⁺, and cMo_CD33^lo, and non-significant changes in cMo_CD9^hiCD33⁺ and cMo_CD9^hiCD62L⁺. Each dot represents an individual patient. (D) Differences in cMo_CD33^hi monocyte subset frequencies between males and females. All p-values displayed in (C, D) were determined by a Mann-Whitney test.