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. 2022 May 1;26(3):207–218. doi: 10.4196/kjpp.2022.26.3.207

Fig. 2. Effect of FGFR inhibition on bone quality and turnover markers.

Fig. 2

Micro/PET-CT mage scan was conducted after FGFR inhibitor (Inh) treatment. (A) Micro-CT scan image of representative animals from each group and summary statistics of averaged HU value. (B) PET-CT scan image of representative animals from each group and summary statistics of averaged SUV (g/ml). Bone turnover markers were measured with qRT-PCR. Gene expression level of (C) osteogenic genes (Osteocalcin, Runx2, and Alp) and (D) osteoclastogenic genes (Opg and Rankl) was normalized with Gapdh. All values are presented as mean ± SEM. FGFR, fibroblast growth factor receptor; PET-CT, positron emission tomography/computed tomography; HU, Hounsfield unit; SUV, standardized uptake values. *p < 0.05, **p < 0.01.