Fig. 7. Schematic diagrams of the blunted adaptation of resistance exercise training during FGFR inhibition.

(A) RET generally provide beneficial effect on bone and muscle quality. (B) FGFR inhibition with NVP-BGJ398 altered bone and muscle quality detrimentally. (C) RET adaptation on bone and muscle were blunted with FGFR inhibition. However, elevated bone resorption was improved. FGFR, fibroblast growth factor receptor; RET, resistance exercise training.