Table 2.
Upstream regulations and biological functions of miR-1224 involved in different cancers.
| Systems | Cancer type | RNAs | Upstream gene | Biological functions | References |
|---|---|---|---|---|---|
| Respiratory system | LC | miR-1224 | NEAT1 | Inhibit proliferation and invasion, promote apoptosis | (19) |
| LAUD | miR-1224-3p | Circ-ZNF609 | Inhibit proliferation and cell cycle | (21) | |
| Nerve system | Glioma | miR-1224-3p | Circ-ZNF609 | Inhibit proliferation, migration and invasion | (24) |
| miR-1224-3p | EZH2 | Inhibit proliferation, invasion and glucose metabolism | (23) | ||
| GBM | miR-1224-5p | MIR44435‐2HG | Inhibit proliferation and invasion, promote apoptosis | (25) | |
| Muscular and skeletal systems | OS | miR-1224-5p | linc00460 | Inhibit proliferation, invasion and migration | (28) |
| miR-1224-5p | \ | Inhibit proliferation, invasion and EMT, promote apoptosis, autophagy | (27) | ||
| Genitourinary system | Bca | miR-1224-5p | circCASC15 | Inhibit proliferation | (29) |
| miR-1224-5p | FOXI1 | Inhibit viability, migration and invasion | (31) | ||
| RCC | miR-1224-3p | circ-EGNL3 | Inhibit proliferation, invasion, and migration | (49) | |
| BC | miR-1224-3p | \ | Inhibit apoptosis, promote EMT, migration and metastasis | (50) | |
| miR-1224-3p | \ | Promote cell growth and metastasis | (32) | ||
| Digestive system | TSCC | miR-1224-5p | IGFL2-AS1 | Inhibit proliferation, migration, invasion and EMT | (33) |
| OSCC | miR-1224-5p | APCDD1L-AS1 | Inhibit proliferation and promote apoptosis | (34) | |
| GC | miR-1224-5p | NEAT1 | Inhibit proliferation, invasion, and migration | (36) | |
| miR-1224 | \ | Inhibit proliferation, migration, invasion, and EMT | (35) | ||
| HCC | miR-1224 | CREB | Inhibit proliferation and cell cycle | (42) | |
| miR-1224 | circRASGRF2 | Inhibit proliferation, cell cycle, invasion, migration and EMT, promote apoptosis, autophagy | (43) | ||
| miR-1224-5p | / | Inhibit proliferation, migration and invasion, promote apoptosis | (44) | ||
| CRC | miR-1224-5p | Circ-RNF121 | Inhibit proliferation, migration, invasion and glycolysis, promote apoptosis | (38) | |
| miR-1224-5p | / | Inhibit migration, invasion and EMT | (39) | ||
| ESCA | miR-1224-5p | Linc00460 | Inhibit migration, invasion and EMT | (41) | |
| PC | miR-1224-5p | Linc00665 | Inhibit proliferation, migration and invasion | (46) | |
| miR-1224-5p | / | Inhibit proliferation, migration, invasion and EMT | (45) | ||
| Skin | Melanoma | miR-1224-5p | ZEB1-AS1 | Inhibit proliferation, migration and invasion | (47) |
| Keloids | miR-1224-5p | / | Inhibit proliferation, migration and invasion, promote apoptosis | (48) |