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. 2022 Apr 14;12:780354. doi: 10.3389/fcimb.2022.780354

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Copyright © 2022 Low, Suleiman, Shamdas, Bassilious, Poonit, Rossiter, Acharjee, Loman, Murray, Wallace and Rauz

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Correlations between alpha diversity [OTUs in Panel (A), and Shannon Index in Panel (B)] and Cicatrising Conjunctivitis Clinical Assessment Tool (CCAT) score of bulbar conjunctival hyperaemia defined as ‘inflammation’ in the worse eye. A higher clinical inflammation score represents a more active clinical disease. Reduced number of observed OTUs were correlated with extent of bulbar conjunctival inflammation (R2: 0.1, p= 0.03). However, there was no significant correlation between Shannon Index and inflammation. OTUs, operational taxonomic units.