TABLE 1.

Identity of the active component

^aThe 26-amino-acid sequence of the FPLC peak derived from the LPS-MUC sample is identical to the N-terminal sequence from trout H1 histone (underlined). The 8-amino-acid sequence obtained from the VIB-SER-derived peak was also identical to the N terminus of the histone. Mass spectroscopic data for both samples revealed a number of histone fragments. The most probable fragmentation pattern is shown by separating the fragments with periods. The section indicated by the wavy underlined likely resulted in fragmentation into many short (∼15-amino-acid) sections. The sequences of the synthetic peptides (HSDF-1 and HSDF-2) used in further experiments are also shown. Ac, acetylation of the N terminus, NH₂, C-terminal amidation.