Table 2.
Top differentially expressed genes identified in the meta-analysis
| Gene Symbol | EVA-PR |
VDKA |
Meta-Analysis |
||||||
|---|---|---|---|---|---|---|---|---|---|
| Average Expression* | Fold-Change | P-value | Average Expression* | Fold-Change | P-value | Fold-Change | P-value | FDR P-value | |
|
| |||||||||
| CXCL11 | 20.26 | 0.88 | 9.75E-06 | 17.62 | 0.61 | 5.27E-08 | 0.86 | 5.86E-09 | 1.04E-04 |
| CXCL9 | 22.31 | 0.88 | 3.70E-05 | 27.07 | 0.63 | 1.98E-06 | 0.85 | 6.55E-08 | 4.38E-04 |
| LGALS17A | 1.13 | 0.91 | 4.54E-05 | 2.69 | 0.65 | 1.47E-07 | 0.88 | 7.40E-08 | 4.38E-04 |
| LOC642366 | 0.66 | 1.21 | 7.46E-06 | 0.32 | 1.35 | 3.98E-03 | 1.22 | 1.73E-07 | 7.68E-04 |
| WARS | 277.20 | 0.86 | 3.09E-04 | 331.55 | 0.61 | 3.99E-06 | 0.82 | 4.78E-07 | 1.70E-03 |
| GRIN3A † | 0.06 | 0.87 | 1.08E-04 | 0.01 | 0.78 | 6.74E-04 | 0.85 | 6.31E-07 | 1.87E-03 |
| CCL8 | 1.19 | 0.92 | 2.50E-05 | 0.22 | 0.79 | 3.79E-03 | 0.91 | 1.65E-06 | 3.90E-03 |
| CNGB3 † | 0.05 | 1.16 | 1.24E-05 | 0.05 | 1.21 | 4.96E-02 | 1.16 | 1.82E-06 | 3.90E-03 |
| SLAMF7 | 7.09 | 0.83 | 1.31E-05 | 4.81 | 0.85 | 5.61E-02 | 0.84 | 1.98E-06 | 3.90E-03 |
| COL26A1 † | 0.09 | 0.86 | 6.47E-06 | 0.07 | 0.88 | 1.96E-01 | 0.86 | 2.77E-06 | 4.92E-03 |
| CXCL10 | 80.23 | 0.91 | 7.83E-04 | 100.95 | 0.65 | 3.49E-06 | 0.88 | 4.43E-06 | 6.55E-03 |
| ZBP1 | 2.73 | 0.88 | 1.11E-03 | 2.66 | 0.64 | 2.12E-05 | 0.85 | 5.74E-06 | 6.96E-03 |
| ISG15 | 121.24 | 0.88 | 9.47E-04 | 154.93 | 0.64 | 2.85E-05 | 0.85 | 5.79E-06 | 6.96E-03 |
| GBP5 | 24.31 | 0.88 | 1.18E-03 | 15.33 | 0.64 | 1.40E-05 | 0.85 | 5.87E-06 | 6.96E-03 |
| LILRB1 | 2.50 | 0.84 | 3.91E-06 | 0.44 | 0.95 | 6.17E-01 | 0.85 | 6.64E-06 | 7.38E-03 |
| GBP1 | 73.30 | 0.89 | 6.41E-03 | 75.43 | 0.57 | 1.54E-07 | 0.85 | 9.41E-06 | 9.84E-03 |
| IL4I1 | 4.51 | 0.86 | 5.68E-05 | 0.94 | 0.83 | 7.57E-02 | 0.85 | 1.13E-05 | 1.12E-02 |
| SOCS1 | 6.66 | 0.88 | 1.09E-03 | 5.11 | 0.69 | 4.32E-04 | 0.86 | 1.93E-05 | 1.80E-02 |
| PDE7A | 9.24 | 1.08 | 6.46E-03 | 6.39 | 1.23 | 9.99E-05 | 1.11 | 2.74E-05 | 2.33E-02 |
| EXOC3L1 † | 0.28 | 0.89 | 3.48E-03 | 0.24 | 0.67 | 8.01E-05 | 0.85 | 2.76E-05 | 2.33E-02 |
| FLJ37201 | 0.84 | 1.15 | 5.17E-04 | 0.21 | 1.25 | 2.28E-02 | 1.17 | 4.58E-05 | 3.70E-02 |
| SPATS2L | 42.34 | 0.93 | 1.92E-02 | 55.74 | 0.77 | 1.45E-05 | 0.90 | 5.16E-05 | 3.99E-02 |
| IL32 | 11.54 | 0.87 | 9.07E-04 | 15.66 | 0.76 | 1.06E-02 | 0.86 | 5.76E-05 | 4.26E-02 |
| GZMB | 12.53 | 0.88 | 6.54E-04 | 5.61 | 0.78 | 1.78E-02 | 0.87 | 6.45E-05 | 4.57E-02 |
| IFI35 | 40.98 | 0.88 | 1.23E-03 | 66.37 | 0.79 | 9.74E-03 | 0.87 | 6.69E-05 | 4.57E-02 |
| RSAD2 | 21.09 | 0.90 | 6.29E-03 | 15.46 | 0.65 | 4.57E-05 | 0.87 | 7.06E-05 | 4.64E-02 |
| SUGT1P1 | 3.99 | 1.09 | 1.32E-02 | 2.26 | 1.33 | 7.40E-05 | 1.13 | 7.31E-05 | 4.64E-02 |
| RRP8 | 17.92 | 1.04 | 1.08E-02 | 14.48 | 1.14 | 9.91E-05 | 1.06 | 7.72E-05 | 4.73E-02 |
| ISG20 | 41.97 | 0.89 | 2.98E-03 | 61.95 | 0.77 | 2.95E-03 | 0.86 | 8.31E-05 | 4.92E-02 |
*
Average expression of genes was calculated based on transcript per million (TPM), which is more comparable across cohorts.
†
Results for genes with TPM < 0.5 should be interpreted with caution.