Skip to main content
. Author manuscript; available in PMC: 2023 Apr 1.
Published in final edited form as: Pediatr Allergy Immunol. 2022 Apr;33(4):e13776. doi: 10.1111/pai.13776

Table 3.

Top gene ontology (GO) biological processes over-represented by the top DEGs in the meta-analysis

GO Biological Process Fold Enrichment P-value FDR-adjusted P-value Gene Symbol

Negative regulation of CD8-positive, alpha-beta T cell activation > 100 4.26E-05 1.32E-02 LILRB1, SOCS1
Interferon-gamma production > 100 8.35E-05 2.31E-02 ISG15, LILRB1
T cell chemotaxis > 100 1.81E-04 4.21E-02 CXCL10, CXCL11
Positive regulation of release of sequestered calcium ion into cytosol 56.58 2.44E-05 8.74E-03 CXCL10, CXCL11, CXCL9
Type I interferon signaling pathway 46.6 1.93E-06 1.38E-03 ISG15, IFI35, RSAD2, ISG20
Negative regulation of viral genome replication 44.01 4.98E-05 1.48E-02 ISG15, RSAD2, ISG20
Neutrophil chemotaxis 41.15 3.09E-06 1.81E-03 CXCL10, CXCL11, CCL8, CXCL9
Chemokine-mediated signaling pathway 40.11 3.41E-06 1.85E-03 CXCL10, CXCL11, CCL8, CXCL9
Killing of cells of other organisms 37.72 4.31E-06 2.19E-03 CXCL10, CXCL11, CCL8, CXCL9
Antimicrobial humoral immune response mediated by antimicrobial peptide 30.76 9.38E-06 3.70E-03 CXCL10, CXCL11, CCL8, CXCL9