Table 1.

Demographics, clinical features, treatment, key initial laboratory and radiographic findings, and outcomes in patients with multisystem inflammatory syndrome in children (MIS-C)

		Patient 1	Patient 2	Patient 3	Patient 4	Patient 5	Patient 6	Patient 7	Patient 8	Patient 9	Patient 10	Patient	Patient	Patient
		(F)	(M)	(M)	(M)	(M)	(F)	(F)	(M)	(M)	(F)	11 (M)	12 (M)	13 (M)
	Age (years)	14.17	16.5	1.17	15.11	0.92	12.5	3.01	0.33	5.58	0.75	17.75	7.58	11.33
	Presenting symptoms	Fever, abdominal pain, nausea, vomiting	Fever, lymphadenopathy, headache, diarrhea, nausea, vomiting, rash, pedal edema	Fever, diarrhea, anorexia, dyspnea, pedal edema	Fever, dyspnea	Fever, diarrhea, dyspnea, cough	Fever, cough, rash, minimal pedal edema	Fatigue, dizziness	Diarrhea, vomiting, dyspnea	Fever, limb weakness, conjunctivitis, diarrhea, dyspnea	Fever, seizure, diarrhea, vomiting	Dyspnea, cough	Fever, nausea, abdominal pain, decreased appetite	Fever, fatigue, lymphadenopathy, headache, seizure, vomiting, transient visual impairment
Clinical findings	Days before admission	0	6	4	7	10	4	1	1	10	3	1	3	7
	Comorbidities	Acute appendicitis with generalized peritonitis	None	Spastic cerebral palsy	None	None	End- stage kidney disease on hemodialysis	Total AV block, infective endocarditis	None	None	Intussusception	End- stage kidney disease on hemodialysis, focal segmental glomerulosclerosis	Acute appendicitis	Hypertensive encephalopathy, nephritic syndrome, neuromyelitis optica, optic neuritis
	Initial oxygen supplementation therapy	No	No	Yes	Yes	Yes	No	No	No	Yes	Yes	Yes	No	Yes
	Presence of shock	Septic shock mimic	None	Hypovolemic	Cardiogenic	Hypovolemic	None	Cardiac, hypovolemic, septic shock mimic	Hypovolemic	None	Hypovolemic	None	Septic shock mimic	None
	Mechanical ventilation	Yes	No	Yes	No	No	No	Yes	No	Yes	Yes	Yes	No	Yes
	Intubation	Yes	No	Yes	No	No	No	Yes	No	Yes	Yes	Yes	Yes	Yes
	Exposure to healthcare facilities or professionals	Yes	Yes	Yes	No	Yes	No	No	Yes	Yes	No	Yes	Yes	Yes
	History of contact with suspected or confirmed cases	No	Yes	No	No	Yes	Yes	No	No	No	No	No	No	No
	Cause of death	Septic shock mimic	–	–	–	–	–	–	–	–	–	ARDS	–	–
Key initial laboratory and radiographic findings	PCR sample	Naso-oropharyngeal	Naso-oropharyngeal and rectal	Naso-oropharyngeal	Naso-oropharyngeal	Naso-oropharyngeal	Naso-oropharyngeal	Naso-oropharyngeal	Naso-oropharyngeal and rectal	Naso-oropharyngeal	Naso-oropharyngeal	Naso-oropharyngeal	Naso-oropharyngeal	Naso-oropharyngeal and ETT aspirate
	PCR results	Positive; Ct value N/A	Negative	Negative	Positive	Positive; Ct value 33.6	Negative	Positivea	Negative	Negative	Negative	Negative	Negative	Negative
	SARS- CoV-2 antibody test	Negative	IgG (+)	IgG (+)	IgM and IgG (+)	N/A	Negative	IgM (+)	IgG (+)	IgG (+)	IgG (+)	IgG (+)	IgM and IgG (+)	IgG (+)
	Chest X-ray	Normal	Lower left lobe infiltrate	Bilateral infiltrate	Cardiomegaly with lung edema, thickening of hilar bilaterally	Infiltrate at right paracardial and bilateral suprahilar and perihilar infiltrate	N/A	Cardiomegaly, inhomogeneous opacity at the apex of right lung, cardiac pacemaker projected in the ventricle	Infiltrate at right upper and lower lobe and left perihilar	Normal	Normal	Inhomogeneous consolidation at both lungs	Normal	Infiltrate at both lungs
	Echocardiography	N/A	Depressed LV function with EF 42%	Normal	Poor contractility	N/A	N/A	Vegetation (+)	N/A	N/A	N/A	Minimal pericardial effusion, EF 69%	N/A	N/A

Note: N/A, not available; M, male; F, female; ER, emergency room; BPM, beats per minute; L, liter; NC, nasal cannula; NRM, non-rebreathing mask; RA, room air; MV, mechanical ventilation; PCR, polymerase chain reaction; Ab, antibody; IgG, immunoglobulin G; IgM, immunoglobulin M; MAP, mean arterial pressure; CRP, C-reactive protein; LV, left ventricle; EF, ejection fraction; MR, mitral regurgitation; TR, tricuspid regurgitation; NS, normal saline; RL, ringer lactate; FiO₂, fraction of inspired oxygen; ETT, endotracheal tube; ARDS, acute respiratory distress syndrome; Ct, cycle threshold; AV, atrio-ventricular.

^aPositive result was obtained from the referring hospital.