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. 2022 Apr 28;17:8. doi: 10.1186/s13062-022-00321-1

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Migrasomes in different contexts. Schematic illustration of migrasomes putative roles in distinct scenarios. In TME cancer cells might release migrasomes to facilitate their intravasation, tissues infiltration and angiogenesis together with the enhancement of the immunosuppressive effects. During the skeletal muscle development, myogenic precursors-derived migrasomes could orchestrate a finely tuned motility of neighboring cells, thereby promoting a more concerted migration towards limbs and body trunk; while, after injury, the muscle-resident stem cells-derived migrasomes may be involved in a more rapid repair of the damage. According to the immune population type, migrasomes could exploit several crucial roles: from regulation, activation or mobilization of other immune cells (migrasomes released by the antigen presenting cells, for example), improvement of target identification (macrophage-derived migrasomes, full of processed antigens) to enhancement of cytotoxic/suppressive ability in an environmental-dependent manner (T cell-derived migrasomes)