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. 2022 Apr 28;365:131974. doi: 10.1016/j.snb.2022.131974

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Fig. 3 — The optimization of Fe₃O₄-Au nanocomposite and the detection of SARS-CoV-2 pseudovirus with the most optimal magnetic SERS biosensor. (a) the TEM images of Fe₃O₄-Au nanocomposite with different growth times from two times to six times (ⅰ-ⅴ). (b) The fluorescence intensity of four samples, letter a: Fe₃O₄-Au-FITC composite, letter b: Fe₃O₄-Au-ACE2-FITC composite, letter c: Fe₃O₄-Au-pseudovirus-FITC composite, letter d：Fe₃O₄-Au-ACE2-pseudovirus-FITC composite. (c) The SERS performance comparation of ACE2 based on magnetic SERS biosensor with different growth times of Au NPs. (d) The structure of magnetic SERS biosensor in detecting pseudovirus. (e) The Raman spectra of SARS-CoV-2 pseudovirus with different viral load from 2.76 × 10⁴ copies/mL to 2.76 × 10² copies/mL, the solid line is the Raman spectra of pseudovirus and the dash line is the fitted Raman shift by Peakfit software.