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. 2022 Apr 28;9:19. doi: 10.1186/s40580-022-00310-0

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Lipid calcium phosphate nanoparticle (LCP NP)-mediated co-delivery of Trp2 peptide and CpG in B16F10 subcutaneous tumor. a Synthesis LCP NPs that encapsulate phosphorylated Trp2 (p-Trp2) and CpG for the delivery into DCs via the mannose receptor. TEM image of b hydrophobic LCP cores and c mannose-functionalized, aqueous LCP NPs. In vivo CTL response assay examining mice immunized with control peptide/CpG or mannose-LCP NPs containing both Trp2/CpG against splenocytes pulsed with d Trp2 or e p-Trp2. f, g Reduction of B16F10 tumor sizes in mice immunized with LCP NPs containing both Trp2 and CpG.

Reproduced with permission from ref [47]