Table 2:

Associations between EPVS percentage area and total CAA

Models with total CAA
	(0) Null model	(1a) CAA only	(2a) With fibrin positive vessels (WM)	(3a) With myelin density	(4a) With cortical Aβ-plaques	(5a) Comprehensive model
Age at death (y)	p = 0.388	p = 0.290	p = 0.287	p = 0.577	p = 0.284	p = 0.570
	−0.014 (−0.047 – 0.018)	−0.016 (−0.047 – 0.014)	−0.017 (−0.049–0.014)	−0.009 (−0.041– 0.023)	−0.016 (−0.047–0.014)	−0.009 (−0.041–0.022)
Sex	p = 0.896	p = 0.994	p = 0.925	p = 0.661	p = 0.848	p = 0.696
	−0.03418 (−0.564 – 0.502)	0.001 (−0.501 – 0.509)	0.025 (−0.503 – 0.594)	0.112 (−0.402–0.631)	−0.048 (−0.554–0.488)	0.106 (−0.431– 0.713)
CAA area (%)		p = 0.037	p = 0.038	p = 0.014	p = 0.047	p = 0.016
		0.280 (0.002 – 0.555)	0.291 (0.004 –0.582)	0.317 (0.060–0.571)	0.266 (−0.019– 0.544)	0.319 (0.048–0.591)
Fibrin positive vessels (WM) (%)			p = 0.797			p = 0.880
			−0.060 (−0.568–0.444)			−0.034 (−0.505–0.446)
Myelin density				p < 0.001		p < 0.001
				0.034 (0.015–0.054)		0.034 (0.014–0.054)
Cortical Aβ-plaques					p = 0.514	p = 0.817
					0.035 (−0.091– 0.152)	0.0123 (−0.112– 0.129)
Log Likelihood	−84.97	−83.02	−83.0	−77.50	−82.9	−77.50
AIC	181.94	180.03	181.98	171.01	181.70	174.98
BIC	195.43	195.77	199.96	189.00	199.69	197.47
Total R2	0.25	0.32	0.34	0.52	0.29	0.51

Table 2 Associations between EPVS percentage area and total CAA. Results for the fixed effects of linear mixed effects models explaining percentage area of EPVS in the white matter of histopathological sections. Subject and cortical region (frontal, temporal, parietal, and occipital) were always set as random factors for the intercept. Data represent standardized fixed effects estimates with confidence intervals and statistical significance. Models were compared using likelihood ratio tests; smaller AIC and BIC values indicate a better model fit. Significant effects are highlighted in bold