Table 2.
The Accuracy of PyloriAR Next-Generation Sequencing in Predicating Helicoobacter pylori Antibiotic Resistance in Culture Isolates
| Antibiotics | PyloriAR NGS culture isolate | Culture (MIC) |
Sensitivity, % | Specificity, % | Predicative value, % |
Accuracy, % | Agreement, k coefficient | ||
|---|---|---|---|---|---|---|---|---|---|
| (+) | (−) | PPV | NPV | ||||||
|
| |||||||||
| Clarithromycin | (+) | 28 | 3 | ||||||
| n = 170 | (−) | 2 | 137 | 93.3 | 97.9 | 90.3 | 98.6 | 97.1 | 0.90012 (P < .0001) |
| 95% CI | — | — | — | 77.9–99.2 | 93.9–99. 6 | 75.2–96.6 | 94.7–99.6 | 93.3–99 | 0.8671–0.9253 |
| Amoxicillin | (+) | 1 | 0 | ||||||
| n = 170 | (−) | 7 | 162 | 12.5 | 100.0 | 100.0 | 95.9 | 95.9 | 0.21400 (P = .0051) |
| 95% CI | — | — | — | 0.3–52.6 | 97.7–100.0 | 94.7–96.8 | 91.7–98.3 | 0.0656–0.3531 | |
| Metronidazole | (+) | 68 | 9 | ||||||
| n = 170 | (−) | 29 | 64 | 70.1 | 87.7 | 88.3 | 68.8 | 77.6% | 0.5588 (P < .0001) |
| 95% CI | — | — | — | 50–79 | 77.9–94.2 | 80.2–93.4 | 61.7–75.2 | 70.63–83.7 | 0.4458–0.6543 |
| Rifabutin | (+) | 0 | 1 | ||||||
| n = 170 | (−) | 0 | 169 | — | 99.4 | 0.00 | 100.0 | — | |
| 95% CI | — | — | — | — | 96.8–100 | — | — | — | |
| Levofloxacin | (+) | 31 | 4 | ||||||
| n = 57 | (−) | 2 | 20 | 93.9 | 83.3 | 88.6 | 90.9 | 89.5 | 0.78161 (P < 0.0001) |
| 95% CI | — | — | — | 79.8–99.3 | 62.6–95.3 | 75.9–95 | 72.1–97.5 | 78.5–96 | 0.61689–0.94633 |
| Tetracycline | (+) | 0 | 0 | ||||||
| n = 57 | (−) | 1 | 56 | 0.00 | 100.0 | — | 98.2 | 98.2 | — |
| 95% CI | — | — | — | 0.00–97.5 | 93.6–100.0 | — | 98.2–98.2 | 90.6–100 | — |
(+), resistant; (−), sensitive; CI, confidence interval.